Statements (39)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
MKPs
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:enzymeClassification |
gptkb:EC_3.1.3.16
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
dephosphorylate MAP kinases
|
| gptkbp:geneExample |
gptkb:DUSP1
gptkb:DUSP10 gptkb:DUSP16 gptkb:DUSP2 gptkb:DUSP4 gptkb:DUSP5 gptkb:DUSP6 gptkb:DUSP7 gptkb:DUSP8 gptkb:DUSP9 |
| https://www.w3.org/2000/01/rdf-schema#label |
MAPK phosphatases
|
| gptkbp:inhibitedBy |
MAPK activity
|
| gptkbp:involves |
gptkb:cancer
neurodegenerative diseases autoimmune diseases inflammatory diseases |
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:memberOf |
dual-specificity phosphatases
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation immune response histone modification protein-protein interactions subcellular localization MAPK signaling pathways transcriptional |
| gptkbp:substrate |
gptkb:JNK
gptkb:p38_MAPK gptkb:ERK |
| gptkbp:bfsParent |
gptkb:Mitogen-activated_protein_kinase
|
| gptkbp:bfsLayer |
7
|