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gptkbp:instanceOf
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gptkb:protein
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gptkbp:activatedBy
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Raf kinases
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gptkbp:alternativeName
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gptkb:MAPKK2
gptkb:Mitogen-activated_protein_kinase_kinase_2
Dual specificity mitogen-activated protein kinase kinase 2
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gptkbp:associatedWith
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gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
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gptkbp:encodedBy
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gptkb:MAP2K2_gene
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gptkbp:enzymeClassification
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gptkb:EC_2.7.12.2
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gptkbp:function
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phosphorylates and activates ERK1/2
involved in MAPK/ERK signaling pathway
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https://www.w3.org/2000/01/rdf-schema#label
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MEK2 protein
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gptkbp:inhibitedBy
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gptkb:Selumetinib
gptkb:Trametinib
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gptkbp:locatedOnChromosome
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gptkb:19p13.3
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
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approximately 44 kDa
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gptkbp:mutationAssociatedWith
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gain-of-function mutations cause developmental syndromes
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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gptkb:mouse_Map2k2
rat Map2k2
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gptkbp:pathway
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gptkb:MAPK_signaling_pathway
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gptkbp:phosphorylates
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Serine 222
Threonine 394
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gptkbp:structure
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contains protein kinase domain
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gptkbp:substrate
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gptkb:ERK1
gptkb:ERK2
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gptkbp:UniProtID
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P36507
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gptkbp:bfsParent
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gptkb:MAP2K2_gene
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gptkbp:bfsLayer
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7
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