|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:MAP3K
|
|
gptkbp:alsoKnownAs
|
gptkb:MAP2K3
gptkb:MKK3
gptkb:MEK3
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune disorders
inflammatory diseases
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:MAP2K3_gene
|
|
gptkbp:Entrez_Gene_ID
|
5606
|
|
gptkbp:enzymeCommissionNumber
|
2.7.12.2
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
serine/threonine protein kinase
activates p38 MAP kinase
|
|
gptkbp:GO_term
|
GO:0000187 (activation of MAPK activity)
GO:0005524 (ATP binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0007165 (signal transduction)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAP kinase kinase 3
|
|
gptkbp:interactsWith
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:TAK1
gptkb:MAPK14
ASK1
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
inflammatory response
cellular response to stress
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:molecularWeight
|
~39 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Map2k3
|
|
gptkbp:PDB
|
2WZV
3F9O
|
|
gptkbp:phosphorylates
|
gptkb:MAPK11
gptkb:MAPK12
gptkb:MAPK13
gptkb:MAPK14
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:structure
|
contains protein kinase domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P46734
|
|
gptkbp:bfsParent
|
gptkb:MKK3
|
|
gptkbp:bfsLayer
|
7
|