|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:MAP4K1
gptkb:HPK-1
gptkb:MEKKK1
gptkb:hematopoietic_progenitor_kinase_1
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:discoveredBy
|
K. Hirai et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodedBy
|
gptkb:MAP4K1_gene
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.25
|
|
gptkbp:fullName
|
gptkb:Hematopoietic_progenitor_kinase_1
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:gene
|
gptkb:MAP4K1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HPK1
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:BLNK
gptkb:GRB2
|
|
gptkbp:involvedIn
|
gptkb:T-cell_receptor_signaling_pathway
immune response regulation
|
|
gptkbp:locatedOnChromosome
|
2q11.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
97 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
6B5N
|
|
gptkbp:phosphorylates
|
gptkb:NFAT
gptkb:JNK
|
|
gptkbp:regulates
|
T cell activation
B cell receptor signaling
|
|
gptkbp:target
|
small molecule inhibitors
|
|
gptkbp:UniProtID
|
Q92918
|
|
gptkbp:bfsParent
|
gptkb:RLY-1971
gptkb:Hematopoietic_Progenitor_Kinase
gptkb:MAP4K1
|
|
gptkbp:bfsLayer
|
7
|