|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD91
gptkb:alpha-2-macroglobulin_receptor
APOER
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
atherosclerosis
lipid metabolism disorders
|
|
gptkbp:binds
|
gptkb:tissue_plasminogen_activator
gptkb:apolipoprotein_E
gptkb:alpha-2-macroglobulin
gptkb:amyloid_precursor_protein
|
|
gptkbp:cleavage
|
alpha chain
beta chain
|
|
gptkbp:encodedBy
|
LRP1 gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
brain
liver
vascular smooth muscle cells
|
|
gptkbp:fullName
|
gptkb:Low-density_lipoprotein_receptor-related_protein_1
|
|
gptkbp:function
|
cell signaling
lipoprotein metabolism
endocytosis
clearance of apoptotic cells
|
|
gptkbp:gene
|
gptkb:LRP1
|
|
gptkbp:HGNC_ID
|
6692
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LRP1 receptor
|
|
gptkbp:interactsWith
|
gptkb:TGF-beta_receptor
gptkb:APP
PDGF receptor
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
12q13.3
|
|
gptkbp:memberOf
|
gptkb:LDL_receptor_family
|
|
gptkbp:molecularWeight
|
~600 kDa
|
|
gptkbp:OMIM
|
107770
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:2FCW
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
cell proliferation
cell migration
inflammation
extracellular matrix remodeling
|
|
gptkbp:UniProtID
|
gptkb:Q07954
|
|
gptkbp:bfsParent
|
gptkb:Apolipoprotein_E
gptkb:ApoE-containing_lipoproteins
|
|
gptkbp:bfsLayer
|
8
|