apolipoprotein E

URI: https://gptkb.org/entity/apolipoprotein_E

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alias	gptkb:Apo-E gptkb:ApoE
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cardiovascular_disease
gptkbp:component	gptkb:chylomicrons gptkb:high-density_lipoproteins gptkb:intermediate-density_lipoproteins gptkb:very_low-density_lipoproteins
gptkbp:discoveredBy	Allen et al.
gptkbp:discoveredIn	1973
gptkbp:encodedBy	gptkb:APOE_gene
gptkbp:expressedIn	brain liver macrophages
gptkbp:foundIn	humans other mammals
gptkbp:function	cholesterol metabolism lipid transport
gptkbp:hasPolymorphism	gptkb:APOE_ε2 gptkb:APOE_ε3 gptkb:APOE_ε4
gptkbp:HGNC_ID	613
https://www.w3.org/2000/01/rdf-schema#label	apolipoprotein E
gptkbp:locatedOnChromosome	gptkb:chromosome_19
gptkbp:molecularWeight	34 kDa
gptkbp:mutationAssociatedWith	decreased Alzheimer's risk (ε2) increased Alzheimer's risk (ε4) normal risk (ε3)
gptkbp:OMIM	107741
gptkbp:PDB	gptkb:1LE2
gptkbp:role	atherosclerosis neuronal repair immunoregulation lipoprotein clearance
gptkbp:structure	299 amino acids
gptkbp:symbol	gptkb:APOE
gptkbp:UniProtID	P02649
gptkbp:bfsParent	gptkb:chylomicrons
gptkbp:bfsLayer	5