|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease
|
|
gptkbp:binds
|
gptkb:heparan_sulfate_proteoglycans
gptkb:LDL_receptor
gptkb:LRP1_receptor
|
|
gptkbp:component
|
gptkb:chylomicrons
gptkb:high-density_lipoproteins
gptkb:intermediate-density_lipoproteins
gptkb:very_low-density_lipoproteins
|
|
gptkbp:discoveredBy
|
Allen et al.
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:encodedBy
|
gptkb:APOE_gene
|
|
gptkbp:expressedIn
|
brain
liver
macrophages
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
cholesterol metabolism
lipid transport
|
|
gptkbp:hasPolymorphism
|
gptkb:APOE_ε2
gptkb:APOE_ε3
gptkb:APOE_ε4
|
|
gptkbp:HGNC_ID
|
613
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Apolipoprotein E
|
|
gptkbp:length
|
299 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
decreased Alzheimer's risk (ε2)
increased Alzheimer's risk (ε4)
normal risk (ε3)
|
|
gptkbp:OMIM
|
107741
|
|
gptkbp:orthologIn
|
gptkb:lion
gptkb:mouse
right
|
|
gptkbp:PDB
|
gptkb:1LE2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
sialylation
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Lipid_Research
gptkb:Nature_Reviews_Neuroscience
|
|
gptkbp:role
|
atherosclerosis
neuronal repair
immunoregulation
lipoprotein clearance
|
|
gptkbp:structure
|
amphipathic alpha helices
|
|
gptkbp:symbol
|
gptkb:APOE
|
|
gptkbp:UniProtID
|
P02649
|
|
gptkbp:bfsParent
|
gptkb:APOE
gptkb:Apoe
gptkb:Apo-E
gptkb:ApoE
|
|
gptkbp:bfsLayer
|
7
|