Low-density lipoprotein receptor-related protein 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:LRP1
gptkbp:alternativeName	gptkb:CD91 gptkb:alpha-2-macroglobulin_receptor
gptkbp:associatedWith	gptkb:Alzheimer's_disease atherosclerosis
gptkbp:domain	EGF-like domains beta-propeller domains complement-type repeats
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000123384
gptkbp:expressedIn	brain liver macrophages smooth muscle cells
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	cell signaling endocytosis regulation of lipid metabolism clearance of apoptotic cells
gptkbp:gene	gptkb:LRP1
https://www.w3.org/2000/01/rdf-schema#label	Low-density lipoprotein receptor-related protein 1
gptkbp:interactsWith	gptkb:tissue_plasminogen_activator gptkb:apolipoprotein_E gptkb:alpha-2-macroglobulin gptkb:amyloid_precursor_protein
gptkbp:involves	cell proliferation cell survival cell migration modulation of inflammation clearance of proteases
gptkbp:locatedOnChromosome	12q13.3
gptkbp:location	gptkb:cell_membrane gptkb:plasma_membrane
gptkbp:member	gptkb:low-density_lipoprotein_receptor_family
gptkbp:molecularWeight	~600 kDa
gptkbp:OMIM	107770
gptkbp:orthologInMouse	gptkb:Lrp1
gptkbp:PDB	gptkb:2FCW
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:receptor_for	lipoproteins extracellular matrix proteins proteinase-inhibitor complexes
gptkbp:structure	single-pass type I membrane protein
gptkbp:UniProtID	gptkb:Q07954
gptkbp:bfsParent	gptkb:LRP1
gptkbp:bfsLayer	7