|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:D_factor
gptkb:HILDA
gptkb:Leukemia_inhibitory_factor_gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
infertility
|
|
gptkbp:discoveredBy
|
Gough et al.
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodes
|
gptkb:Leukemia_inhibitory_factor
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000128313
3976
|
|
gptkbp:expressedIn
|
gptkb:placenta
various tissues
bone marrow
uterus
|
|
gptkbp:function
|
regulation of cell differentiation
cytokine activity
maintenance of embryonic stem cell pluripotency
|
|
gptkbp:HGNC_ID
|
6596
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LIF gene
|
|
gptkbp:locatedOnChromosome
|
chromosome 22
|
|
gptkbp:medicalUse
|
potential target in cancer therapy
potential target in regenerative medicine
|
|
gptkbp:mutationAssociatedWith
|
can cause infertility
can affect embryonic development
|
|
gptkbp:OMIM
|
159540
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Lif_gene
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:product
|
gptkb:LIF_protein
|
|
gptkbp:proteinFamily
|
gptkb:interleukin-6_family
|
|
gptkbp:recipient
|
gptkb:LIF_receptor_(LIFR)
|
|
gptkbp:regulates
|
cell proliferation
cell survival
inflammation
hematopoiesis
implantation
|
|
gptkbp:UniProtID
|
gptkb:P15018
|
|
gptkbp:bfsParent
|
gptkb:LIF
gptkb:leukemia_inhibitory_factor
|
|
gptkbp:bfsLayer
|
7
|