Leukemia Inhibitory Factor

URI: https://gptkb.org/entity/Leukemia_Inhibitory_Factor
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf cytokine
gptkbp:abbreviation gptkb:LIF
gptkbp:alternativeName gptkb:D_factor
gptkb:HILDA
melanoma-derived LIF
gptkbp:associatedWith gptkb:cancer
leukemia
inflammatory diseases
infertility
gptkbp:discoveredBy Gough et al.
gptkbp:discoveredIn 1987
gptkbp:encodedBy gptkb:LIF_gene
gptkbp:Entrez_Gene_ID 3976
gptkbp:family gptkb:interleukin-6_family
gptkbp:function regulation of cell differentiation
modulation of immune response
maintenance of embryonic stem cell pluripotency
inhibition of differentiation in mouse embryonic stem cells
inhibition of myeloid leukemia cell proliferation
promotion of cell survival
gptkbp:gene gptkb:LIF
gptkbp:HGNC_ID 6596
https://www.w3.org/2000/01/rdf-schema#label Leukemia Inhibitory Factor
gptkbp:isGlycosylated true
gptkbp:isSecreted true
gptkbp:locatedOnChromosome gptkb:22q12.1_(human)
gptkbp:medicalUse cancer research
fertility treatment research
stem cell culture
gptkbp:molecularWeight ~20 kDa
gptkbp:OMIM 159540
gptkbp:pathway gptkb:MAPK_pathway
gptkb:JAK/STAT_pathway
gptkbp:producedBy gptkb:T_cells
macrophages
fibroblasts
endometrial cells
gptkbp:recipient gptkb:gp130
gptkb:LIF_receptor
gptkbp:role neural development
bone metabolism
hematopoiesis
implantation
gptkbp:species gptkb:human
gptkb:mouse
gptkbp:structure gptkb:protein
gptkbp:UniProtID gptkb:P15018
gptkbp:bfsParent gptkb:LIF
gptkbp:bfsLayer 7