|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:LDH-A
muscle-type lactate dehydrogenase
|
|
gptkbp:associatedWith
|
gptkb:LDHA_deficiency
glycogen storage disease XI
|
|
gptkbp:catalyzes
|
conversion of pyruvate to lactate
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:discoveredBy
|
1950s
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:encodedBy
|
gptkb:LDHA_gene
|
|
gptkbp:Entrez_Gene_ID
|
3939
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
other mammals
|
|
gptkbp:gene
|
gptkb:LDHA
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lactate dehydrogenase A
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
gossypol
|
|
gptkbp:involves
|
glycolysis
anaerobic metabolism
|
|
gptkbp:locatedOnChromosome
|
chromosome 11p15.4 (human)
|
|
gptkbp:molecularWeight
|
36 kDa (approximate)
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:PDB
|
1I10
|
|
gptkbp:significance
|
elevated in some cancers
marker for tissue damage
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subunit
|
lactate dehydrogenase enzyme complex
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDHA
|
|
gptkbp:bfsLayer
|
7
|