|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
arginine
histidine
|
|
gptkbp:CASNumber
|
9001-60-9
|
|
gptkbp:catalyzes
|
conversion of lactate to pyruvate
conversion of pyruvate to lactate
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Fritz_Meyerhof
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
red blood cells
|
|
gptkbp:gene
|
gptkb:LDHA
gptkb:LDHB
gptkb:LDHC
gptkb:LDHD
gptkb:LDHE
|
|
gptkbp:hasIsoform
|
gptkb:LDH-A
gptkb:LDH-B
gptkb:LDH-C
gptkb:LDH-D
gptkb:LDH-E
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lactate dehydrogenase
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
malonate
gossypol
|
|
gptkbp:molecularWeight
|
~36 kDa (per subunit)
|
|
gptkbp:PDB
|
gptkb:1I10_(human_LDHA)
|
|
gptkbp:presentIn
|
all living organisms
|
|
gptkbp:relatedTo
|
gptkb:anaerobic_glycolysis
gptkb:Cori_cycle
|
|
gptkbp:significance
|
elevated in hemolytic anemia
elevated in liver disease
elevated in myocardial infarction
elevated in some cancers
elevated in tissue damage
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:UniProtID
|
gptkb:P00338_(human_LDHA)
|
|
gptkbp:usedFor
|
biomarker for tissue damage
marker for hemolysis
marker for liver disease
marker for myocardial infarction
marker for some cancers
|
|
gptkbp:bfsParent
|
gptkb:Warburg_effect
|
|
gptkbp:bfsLayer
|
5
|