|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:LDH-M
gptkb:muscle-type_LDH
|
|
gptkbp:associatedWith
|
gptkb:anaerobic_glycolysis
|
|
gptkbp:cofactor
|
gptkb:NADH
NAD+
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:encodedBy
|
gptkb:LDHA_gene
|
|
gptkbp:fullName
|
gptkb:Lactate_dehydrogenase_A
|
|
gptkbp:function
|
catalyzes conversion of pyruvate to lactate
|
|
gptkbp:gene
|
gptkb:LDHA
|
|
gptkbp:HGNC_ID
|
6541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDH-A
|
|
gptkbp:inhibitedBy
|
gptkb:oxamate
|
|
gptkbp:locatedOnChromosome
|
gptkb:human_chromosome_11p15.4
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:LDH-A_deficiency
|
|
gptkbp:OMIM
|
150000
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
|
|
gptkbp:overexpressedIn
|
many cancers
|
|
gptkbp:pathway
|
glycolysis
gluconeogenesis
|
|
gptkbp:PDB
|
1I10
|
|
gptkbp:product
|
lactate
|
|
gptkbp:significance
|
biomarker for tissue damage
marker for cancer metabolism
|
|
gptkbp:structure
|
homotetramer or heterotetramer
|
|
gptkbp:substrate
|
gptkb:pyruvate
|
|
gptkbp:subunit
|
lactate dehydrogenase tetramer
|
|
gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
liver
|
|
gptkbp:UniProtID
|
gptkb:P00338
|
|
gptkbp:bfsParent
|
gptkb:LDH
gptkb:lactate_dehydrogenase
|
|
gptkbp:bfsLayer
|
6
|