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gptkbp:instanceOf
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gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:EC_1.1.1.27
gptkb:lactic_acid_dehydrogenase
LD
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Fritz_Meyerhof
|
|
gptkbp:discoveredIn
|
1909
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:foundIn
|
gptkb:Bacteria
plants
human body
animal tissues
|
|
gptkbp:fullName
|
gptkb:lactate_dehydrogenase
|
|
gptkbp:function
|
catalyzes the conversion of lactate to pyruvate
|
|
gptkbp:gene
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gptkb:LDHA
gptkb:LDHB
gptkb:LDHC
gptkb:LDHD
gptkb:LDHE
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LDH
|
|
gptkbp:isoenzymes
|
gptkb:LDH-1
gptkb:LDH-2
gptkb:LDH-3
gptkb:LDH-4
gptkb:LDH-5
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:measures
|
gptkb:plasma
urine
blood tests
serum
cerebrospinal fluid
|
|
gptkbp:molecularWeight
|
~140 kDa
|
|
gptkbp:significance
|
elevated in liver disease
elevated in myocardial infarction
elevated in some cancers
elevated in hemolysis
marker for tissue damage
|
|
gptkbp:structure
|
tetrameric protein
|
|
gptkbp:subunitTypes
|
gptkb:LDH-A
gptkb:LDH-B
gptkb:LDH-C
gptkb:LDH-D
gptkb:LDH-E
|
|
gptkbp:type
|
lactate + NAD+ ⇌ pyruvate + NADH + H+
|
|
gptkbp:usedIn
|
diagnosis of hemolytic anemia
diagnosis of certain cancers
diagnosis of heart attack
diagnosis of liver disease
monitoring tissue damage
|
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gptkbp:bfsParent
|
gptkb:Ludhiana_Junction
|
|
gptkbp:bfsLayer
|
5
|