|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:CASNumber
|
9001-60-9
|
|
gptkbp:catalyzes
|
conversion of lactate to pyruvate
conversion of pyruvate to lactate
|
|
gptkbp:clinical_marker_for
|
gptkb:cancer
gptkb:liver_disease
myocardial infarction
tissue damage
hemolysis
|
|
gptkbp:cofactor
|
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Otto_Fritz_Meyerhof
|
|
gptkbp:EC_number
|
1.1.1.27
|
|
gptkbp:foundIn
|
gptkb:cytoplasm
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
erythrocytes
|
|
gptkbp:gene
|
gptkb:LDHA
gptkb:LDHB
gptkb:LDHC
gptkb:LDHD
|
|
gptkbp:GO_term
|
gptkb:GO:0004459
|
|
gptkbp:hasIsoform
|
gptkb:LDH-1
gptkb:LDH-2
gptkb:LDH-3
gptkb:LDH-4
gptkb:LDH-5
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Lactate dehydrogenase
|
|
gptkbp:inhibitedBy
|
oxalate
pyruvate (at high concentrations)
|
|
gptkbp:molecularWeight
|
~140 kDa (tetramer)
|
|
gptkbp:PDB
|
gptkb:1I10_(human_LDHA)
|
|
gptkbp:product
|
gptkb:pyruvate
gptkb:NADH
lactate
NAD+
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:substrate
|
gptkb:pyruvate
lactate
|
|
gptkbp:subunit
|
H (heart)
M (muscle)
|
|
gptkbp:UniProtID
|
gptkb:P00338_(human_LDHA)
|
|
gptkbp:used_in
|
gptkb:anaerobic_glycolysis
gptkb:Cori_cycle
clinical diagnostics
lactic acid fermentation
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|