|
gptkbp:instanceOf
|
gptkb:G_protein-coupled_receptor
opioid
|
|
gptkbp:alternativeName
|
gptkb:KOR
OP2 receptor
kappa receptor
|
|
gptkbp:associatedWith
|
gptkb:depression
addiction
schizophrenia
anxiety
pain disorders
|
|
gptkbp:discoveredBy
|
gptkb:Brady_et_al.
|
|
gptkbp:discoveredIn
|
1976
|
|
gptkbp:drugClass
|
inhibitory receptor
|
|
gptkbp:encodedBy
|
gptkb:OPRK1_gene
|
|
gptkbp:endogenousLigand
|
gptkb:dynorphin
|
|
gptkbp:enemyOf
|
gptkb:butorphanol
gptkb:nalbuphine
gptkb:naloxone
gptkb:salvinorin_A
gptkb:buprenorphine
gptkb:naltrexone
gptkb:5'-GNTI
gptkb:JDTic
gptkb:U-50488
gptkb:diprenorphine
gptkb:levallorphan
gptkb:nor-BNI
nalmefene
BRL-52537
bremazocine
enadoline
ethylketocyclazocine
oxilorphan
pentazocine
spiradoline
|
|
gptkbp:Entrez_Gene_ID
|
4986 (human)
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
central nervous system
peripheral tissues
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
regulation of mood
regulation of stress response
regulation of consciousness
modulation of pain perception
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Kappa opioid receptor
|
|
gptkbp:IUPHAR_ID
|
319
|
|
gptkbp:ligand
|
gptkb:dynorphin
|
|
gptkbp:locatedOnChromosome
|
chromosome 8q11.23 (human)
|
|
gptkbp:membraneLocation
|
gptkb:cell_membrane
|
|
gptkbp:receptorFamily
|
gptkb:opioid_receptor_family
|
|
gptkbp:receptorSubtype
|
kappa subtype
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:type
|
inhibits adenylate cyclase
activates potassium channels
inhibits calcium channels
|
|
gptkbp:UniProtID
|
gptkb:P41145
|
|
gptkbp:bfsParent
|
gptkb:Opioids
|
|
gptkbp:bfsLayer
|
7
|