|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
immunodeficiency
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
gptkb:JAK3_gene
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:fullName
|
gptkb:Janus_kinase_3
|
|
gptkbp:function
|
signal transduction
tyrosine kinase activity
|
|
gptkbp:gene
|
gptkb:JAK3
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Jak3
|
|
gptkbp:inhibitedBy
|
gptkb:ruxolitinib
gptkb:tofacitinib
|
|
gptkbp:interactsWith
|
gptkb:common_gamma_chain_(IL2RG)
gptkb:STAT5
|
|
gptkbp:involvedIn
|
immune system regulation
cytokine receptor signaling
|
|
gptkbp:location
|
chromosome 19p13.1
|
|
gptkbp:molecularWeight
|
~125 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency
|
|
gptkbp:OMIM
|
600173
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4HVI
|
|
gptkbp:phosphorylates
|
gptkb:STAT6
gptkb:STAT3
gptkb:STAT5
|
|
gptkbp:relatedTo
|
gptkb:JAK2
gptkb:JAK1
gptkb:TYK2
|
|
gptkbp:structure
|
contains FERM, SH2, and kinase domains
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P52333
|
|
gptkbp:bfsParent
|
gptkb:JAN3
gptkb:JAK3
|
|
gptkbp:bfsLayer
|
7
|