|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:JAK-3
JAK3 protein
|
|
gptkbp:associatedWith
|
immunodeficiency
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
gptkb:JAK3_gene
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
tyrosine kinase activity
|
|
gptkbp:gene
|
gptkb:JAK3
|
|
gptkbp:HGNC_ID
|
6192
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Janus kinase 3
|
|
gptkbp:interactsWith
|
gptkb:common_gamma_chain_(IL2RG)
|
|
gptkbp:involves
|
immune system regulation
cytokine receptor signaling
|
|
gptkbp:locatedIn
|
gptkb:human_chromosome_19
|
|
gptkbp:member
|
gptkb:Janus_kinase_family
|
|
gptkbp:molecularWeight
|
125 kDa
|
|
gptkbp:mutationAssociatedWith
|
autosomal recessive severe combined immunodeficiency
|
|
gptkbp:OMIM
|
600173
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
4HVI
|
|
gptkbp:phosphorylates
|
gptkb:STAT6
gptkb:STAT3
gptkb:STAT5
|
|
gptkbp:requires
|
lymphocyte development
|
|
gptkbp:target
|
gptkb:tofacitinib
|
|
gptkbp:UniProtID
|
gptkb:P52333
|
|
gptkbp:bfsParent
|
gptkb:JAN3
gptkb:JAK3
|
|
gptkbp:bfsLayer
|
7
|