gptkbp:instanceOf
|
gptkb:protein
|
gptkbp:alternativeSplicing
|
yes
|
gptkbp:associatedWith
|
Lymphoma
Leukemia
Severe combined immunodeficiency (SCID)
|
gptkbp:biologicalProcess
|
cell proliferation
signal transduction
immune response
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105639
3718
|
gptkbp:enzymeClassification
|
EC 2.7.10.2
|
gptkbp:fullName
|
Tyrosine-protein kinase JAK3
|
gptkbp:function
|
protein tyrosine kinase activity
Non-receptor tyrosine kinase involved in cytokine receptor signaling
|
gptkbp:gene
|
gptkb:JAK3
|
gptkbp:HGNC_ID
|
6192
|
https://www.w3.org/2000/01/rdf-schema#label
|
JAK3 HUMAN
|
gptkbp:interactsWith
|
gptkb:STAT5A
gptkb:STAT5B
gptkb:IL2RG
gptkb:IL2RB
|
gptkbp:length
|
1124 amino acids
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.1
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
gptkbp:molecularWeight
|
125 kDa
|
gptkbp:mutationAssociatedWith
|
Loss-of-function mutations cause SCID
Gain-of-function mutations associated with leukemia
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
gptkbp:orthologIn
|
Jak3_MOUSE
Jak3_RAT
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
|
gptkbp:PDB
|
4HVI
5LWM
5TTV
|
gptkbp:phosphorylates
|
Y980
Y981
|
gptkbp:RefSeq
|
NP_000206.2
|
gptkbp:structure
|
Contains SH2 domain
Contains protein kinase domain
|
gptkbp:targetOfDrug
|
Decernotinib
Ruxolitinib
Tofacitinib
|
gptkbp:tissue_specificity
|
Hematopoietic cells
|
gptkbp:UniProtID
|
gptkb:P52333
|
gptkbp:bfsParent
|
gptkb:JAK3
|
gptkbp:bfsLayer
|
7
|