JAK3 HUMAN

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeSplicing yes
gptkbp:associatedWith Lymphoma
Leukemia
Severe combined immunodeficiency (SCID)
gptkbp:biologicalProcess cell proliferation
signal transduction
immune response
gptkbp:Entrez_Gene_ID gptkb:ENSG00000105639
3718
gptkbp:enzymeClassification EC 2.7.10.2
gptkbp:fullName Tyrosine-protein kinase JAK3
gptkbp:function protein tyrosine kinase activity
Non-receptor tyrosine kinase involved in cytokine receptor signaling
gptkbp:gene gptkb:JAK3
gptkbp:HGNC_ID 6192
https://www.w3.org/2000/01/rdf-schema#label JAK3 HUMAN
gptkbp:interactsWith gptkb:STAT5A
gptkb:STAT5B
gptkb:IL2RG
gptkb:IL2RB
gptkbp:length 1124 amino acids
gptkbp:locatedOnChromosome gptkb:19p13.1
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight 125 kDa
gptkbp:mutationAssociatedWith Loss-of-function mutations cause SCID
Gain-of-function mutations associated with leukemia
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn Jak3_MOUSE
Jak3_RAT
gptkbp:pathway gptkb:JAK-STAT_signaling_pathway
gptkbp:PDB 4HVI
5LWM
5TTV
gptkbp:phosphorylates Y980
Y981
gptkbp:RefSeq NP_000206.2
gptkbp:structure Contains SH2 domain
Contains protein kinase domain
gptkbp:targetOfDrug Decernotinib
Ruxolitinib
Tofacitinib
gptkbp:tissue_specificity Hematopoietic cells
gptkbp:UniProtID gptkb:P52333
gptkbp:bfsParent gptkb:JAK3
gptkbp:bfsLayer 7