|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:CD11b
CR3A
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
Integrin alpha M
|
|
gptkbp:Entrez_Gene_ID
|
3684
ENSG00000169896
|
|
gptkbp:expressedIn
|
macrophages
myeloid cells
monocytes
granulocytes
|
|
gptkbp:formsComplexWith
|
ITGB2 gene product
|
|
gptkbp:formsProteinComplex
|
gptkb:Mac-1
|
|
gptkbp:function
|
involved in inflammation
binds iC3b
complement receptor activity
mediates adhesion of leukocytes to endothelium
|
|
gptkbp:hasBiomarker
|
myeloid cell identification
|
|
gptkbp:HGNC_ID
|
6156
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ITGAM gene
|
|
gptkbp:interactsWith
|
gptkb:ICAM-1
gptkb:fibrinogen
gptkb:CD54
gptkb:factor_X
gptkb:CD18
gptkb:CD47
gptkb:CD40L
complement component iC3b
|
|
gptkbp:involvedIn
|
immune response
phagocytosis
cell adhesion
leukocyte migration
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
16
|
|
gptkbp:mutationAssociatedWith
|
gptkb:systemic_lupus_erythematosus
autoimmune diseases
|
|
gptkbp:OMIM
|
120980
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Itgam
|
|
gptkbp:product
|
CD11b protein
|
|
gptkbp:proteinFamily
|
transmembrane domain
I-domain
cytoplasmic tail
beta-propeller domain
integrin alpha chain family
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
P20702
|
|
gptkbp:bfsParent
|
gptkb:complement_receptor_3
gptkb:integrin_alpha_M_(CD11b)
gptkb:CD11b
|
|
gptkbp:bfsLayer
|
7
|