|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:IAP
integrin-associated protein
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
immune response
cell adhesion
receptor activity
protein binding
integrin binding
negative regulation of phagocytosis
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:encodedBy
|
CD47 gene
|
|
gptkbp:Entrez_Gene_ID
|
961
|
|
gptkbp:expressedIn
|
many cell types
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell surface receptor
regulation of immune response
inhibits phagocytosis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1668
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD47
|
|
gptkbp:inhibitedBy
|
macrophage phagocytosis
|
|
gptkbp:interactsWith
|
gptkb:SIRPα
thrombospondin-1
|
|
gptkbp:ligand
|
gptkb:SIRPα
thrombospondin-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_3
3q13.12
|
|
gptkbp:molecularWeight
|
~50 kDa
|
|
gptkbp:OMIM
|
601028
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
2JJS
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:role
|
angiogenesis
apoptosis regulation
cell adhesion
inflammatory response
cancer immune evasion
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:transmembraneDomains
|
5
|
|
gptkbp:UniProtID
|
Q08722
|
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_superfamily
gptkb:SIRPA
|
|
gptkbp:bfsLayer
|
7
|