|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CD126
Interleukin-6 receptor subunit alpha
|
|
gptkbp:associatedWith
|
asthma
cardiovascular diseases
autoimmune diseases
rheumatoid arthritis
|
|
gptkbp:cellSurfaceExpression
|
various immune cells
|
|
gptkbp:component
|
IL-6 receptor complex
|
|
gptkbp:encodedBy
|
gptkb:IL6R_gene
|
|
gptkbp:Entrez_Gene_ID
|
3570
ENSG00000160712
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
gptkb:B_cells
gptkb:T_cells
macrophages
monocytes
neutrophils
some epithelial cells
|
|
gptkbp:formsComplexWith
|
gptkb:gp130
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
binds interleukin-6
mediates IL-6 signaling
|
|
gptkbp:glycosylation
|
N-linked glycosylation
|
|
gptkbp:HGNC_ID
|
6018
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL6R alpha chain
|
|
gptkbp:involvedIn
|
immune response
inflammatory response
|
|
gptkbp:isSolubleIn
|
soluble IL6R (sIL6R)
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:molecularWeight
|
approximately 80 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Castleman_disease
inflammatory diseases
COVID-19 severity
systemic juvenile idiopathic arthritis
|
|
gptkbp:OMIM
|
147880
|
|
gptkbp:PDB
|
1N26
|
|
gptkbp:regulates
|
regulated by cytokines
shedding by ADAM17
|
|
gptkbp:sequence
|
468 amino acids
|
|
gptkbp:speciesHomolog
|
mouse IL6R alpha chain
rat IL6R alpha chain
|
|
gptkbp:structure
|
extracellular domain, transmembrane domain, cytoplasmic domain
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
|
|
gptkbp:UniProtID
|
P08887
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6_receptor
gptkb:IL-6_receptor
|
|
gptkbp:bfsLayer
|
7
|