|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD126
gptkb:IL-6R
IL6RA
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
asthma
autoimmune diseases
inflammatory diseases
coronary heart disease
rheumatoid arthritis
|
|
gptkbp:discoveredBy
|
1988
|
|
gptkbp:encodes
|
interleukin-6 receptor protein
|
|
gptkbp:Entrez_Gene_ID
|
3570
ENSG00000160712
|
|
gptkbp:expressedIn
|
liver
endothelial cells
immune cells
|
|
gptkbp:fullName
|
interleukin 6 receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
6019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL6R gene
|
|
gptkbp:length
|
468 amino acids
|
|
gptkbp:located_on_strand
|
plus
|
|
gptkbp:locatedOnChromosome
|
1
1q21.3
|
|
gptkbp:mutationAssociatedWith
|
can alter immune response
|
|
gptkbp:OMIM
|
147880
|
|
gptkbp:orthologInMouse
|
Il6r
|
|
gptkbp:pathway
|
gptkb:JAK/STAT_signaling_pathway
cytokine-cytokine receptor interaction
|
|
gptkbp:product
|
gptkb:IL-6R
|
|
gptkbp:protein_function
|
binds interleukin-6
mediates IL-6 signaling
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
|
|
gptkbp:UniProtID
|
P08887
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6_receptor
gptkb:IL-6_receptor
gptkb:interleukin-6_receptor_complex
|
|
gptkbp:bfsLayer
|
7
|