|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:associatedWith
|
gptkb:atopic_dermatitis
asthma
allergic rhinitis
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:IL4_gene
|
|
gptkbp:enemyOf
|
gptkb:dupilumab
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:IL4
gptkb:ENSG00000113520
3565
|
|
gptkbp:expressedIn
|
lymphoid tissues
peripheral blood
|
|
gptkbp:function
|
induces class switching to IgE
promotes Th2 cell differentiation
stimulates B-cell proliferation
|
|
gptkbp:gene
|
gptkb:IL4
|
|
gptkbp:HGNC_ID
|
6014
|
|
gptkbp:homologInRat
|
gptkb:Il4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-4
|
|
gptkbp:inhibitedBy
|
Th1 cell differentiation
macrophage pro-inflammatory activity
|
|
gptkbp:involvedIn
|
allergic response
immune regulation
|
|
gptkbp:length
|
129 amino acids
|
|
gptkbp:locatedOnChromosome
|
5q31.1
|
|
gptkbp:MeSH_ID
|
D015242
|
|
gptkbp:molecularWeight
|
15 kDa
|
|
gptkbp:OMIM
|
147780
|
|
gptkbp:orthologInMouse
|
gptkb:Il4
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine-cytokine receptor interaction
allergic inflammation pathway
|
|
gptkbp:PDB
|
2B8U
|
|
gptkbp:producedBy
|
gptkb:basophils
gptkb:mast_cells
activated T cells
|
|
gptkbp:promotion
|
IgE production
IgG1 production
B cell growth
|
|
gptkbp:recipient
|
gptkb:interleukin-4_receptor
|
|
gptkbp:regulates
|
macrophage activation
MHC class II expression
eosinophil migration
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-4
|
|
gptkbp:target
|
gptkb:anti-IL-4_antibodies
|
|
gptkbp:UniProtID
|
P05112
|
|
gptkbp:bfsParent
|
gptkb:CD4+_T_cells
gptkb:Dupixent
|
|
gptkbp:bfsLayer
|
6
|