|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
gptkb:atopic_dermatitis
allergic rhinitis
|
|
gptkbp:component
|
extracellular space
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:IL4_gene
|
|
gptkbp:enemyOf
|
gptkb:Dupilumab
|
|
gptkbp:Entrez_Gene_ID
|
3565
|
|
gptkbp:fullName
|
gptkb:Interleukin_4
|
|
gptkbp:function
|
cytokine activity
induces class switching to IgE
inhibits Th1 cell differentiation
promotes Th2 cell differentiation
stimulates B cell proliferation
|
|
gptkbp:gene
|
gptkb:IL4
|
|
gptkbp:GOProcess
|
immune response
|
|
gptkbp:HGNC_ID
|
6014
|
|
gptkbp:homologInRat
|
gptkb:Il4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL4
|
|
gptkbp:involvedIn
|
allergic response
immune regulation
asthma pathogenesis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q31.1
|
|
gptkbp:molecularWeight
|
15 kDa
|
|
gptkbp:OMIM
|
147780
|
|
gptkbp:orthologInMouse
|
gptkb:Il4
|
|
gptkbp:PDB
|
2B8U
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:producedBy
|
gptkb:basophils
gptkb:mast_cells
gptkb:T_helper_2_cells
|
|
gptkbp:recipient
|
gptkb:IL-4_receptor
|
|
gptkbp:regulates
|
immunoglobulin class switching
|
|
gptkbp:structure
|
monomeric protein
|
|
gptkbp:target
|
monoclonal antibodies
|
|
gptkbp:UniProtID
|
P05112
|
|
gptkbp:bfsParent
|
gptkb:chromosome_5
|
|
gptkbp:bfsLayer
|
5
|