|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:IL4_gene
|
|
gptkbp:enemyOf
|
gptkb:pitrakinra
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113520
3565
|
|
gptkbp:expressedIn
|
lymphoid tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
B cell differentiation
regulation of immune response
IgE class switching
T helper 2 cell differentiation
|
|
gptkbp:HGNC_ID
|
6014
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin 4
|
|
gptkbp:inducedBy
|
CD23 expression
VCAM-1 expression
|
|
gptkbp:inhibitedBy
|
Th1 cell differentiation
|
|
gptkbp:length
|
153 amino acids
|
|
gptkbp:locatedOnChromosome
|
5q31.1
|
|
gptkbp:molecularWeight
|
15 kDa
|
|
gptkbp:OMIM
|
147780
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2B8U
|
|
gptkbp:producedBy
|
gptkb:basophils
gptkb:mast_cells
gptkb:T_helper_2_cells
|
|
gptkbp:promotion
|
B cell proliferation
MHC class II expression
|
|
gptkbp:recipient
|
interleukin 4 receptor
|
|
gptkbp:regulates
|
eosinophil migration
macrophage polarization
|
|
gptkbp:relatedTo
|
gptkb:atopic_dermatitis
asthma
allergic response
|
|
gptkbp:structure
|
four-helix bundle
|
|
gptkbp:symbol
|
gptkb:IL-4
|
|
gptkbp:targetOfDrug
|
gptkb:dupilumab
|
|
gptkbp:UniProtID
|
P05112
|
|
gptkbp:bfsParent
|
gptkb:NM_000558
gptkb:IL4_gene
|
|
gptkbp:bfsLayer
|
7
|