Homeobox protein NANOG

GPTKB entity

Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:Homeobox_transcription_factor_Nanog
gptkb:hNanog
Homeobox protein NANOGP8
Nanog homeobox protein
gptkbp:associatedWith stem cell biology
cancer stem cells
gptkbp:discoveredBy gptkb:Austin_Smith
gptkbp:discoveredIn 2003
gptkbp:domain homeobox domain
gptkbp:encodedBy gptkb:NANOG_gene
gptkbp:Entrez_Gene_ID 79923
gptkbp:expressedIn induced pluripotent stem cells
embryonic stem cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function transcription factor
maintenance of pluripotency
self-renewal of embryonic stem cells
gptkbp:gene gptkb:NANOG
https://www.w3.org/2000/01/rdf-schema#label Homeobox protein NANOG
gptkbp:interactsWith gptkb:OCT4
gptkb:SOX2
gptkbp:locatedOnChromosome gptkb:12p13.31
gptkbp:location gptkb:nucleus
gptkbp:molecularWeight ~35 kDa
gptkbp:mutationAssociatedWith tumorigenesis
germ cell tumors
teratocarcinoma
gptkbp:orthologIn Nanog (chicken)
Nanog (mouse)
Nanog (zebrafish)
gptkbp:PDB 2X47
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:proteinFamily homeobox genes
gptkbp:regulates gene expression
cell fate determination
differentiation suppression
pluripotency network
gptkbp:relatedTo gptkb:KLF4
gptkb:c-Myc
gptkb:SOX2
gptkb:POU5F1
LIN28
gptkbp:sequence 305 amino acids
gptkbp:UniProtID Q9H9S0
gptkbp:bfsParent gptkb:NANOG
gptkb:Nanog
gptkbp:bfsLayer 7