|
gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Homeobox_transcription_factor_Nanog
gptkb:hNanog
Homeobox protein NANOGP8
Nanog homeobox protein
|
|
gptkbp:associatedWith
|
stem cell biology
cancer stem cells
|
|
gptkbp:discoveredBy
|
gptkb:Austin_Smith
|
|
gptkbp:discoveredIn
|
2003
|
|
gptkbp:domain
|
homeobox domain
|
|
gptkbp:encodedBy
|
gptkb:NANOG_gene
|
|
gptkbp:Entrez_Gene_ID
|
79923
|
|
gptkbp:expressedIn
|
induced pluripotent stem cells
embryonic stem cells
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:transcription_factor
maintenance of pluripotency
self-renewal of embryonic stem cells
|
|
gptkbp:gene
|
gptkb:NANOG
|
|
gptkbp:interactsWith
|
gptkb:OCT4
gptkb:SOX2
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13.31
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~35 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
germ cell tumors
teratocarcinoma
|
|
gptkbp:orthologIn
|
Nanog (chicken)
Nanog (mouse)
Nanog (zebrafish)
|
|
gptkbp:PDB
|
2X47
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:homeobox_genes
|
|
gptkbp:regulates
|
gene expression
cell fate determination
differentiation suppression
pluripotency network
|
|
gptkbp:relatedTo
|
gptkb:KLF4
gptkb:c-Myc
gptkb:SOX2
gptkb:POU5F1
LIN28
|
|
gptkbp:sequence
|
305 amino acids
|
|
gptkbp:UniProtID
|
Q9H9S0
|
|
gptkbp:bfsParent
|
gptkb:NANOG
gptkb:Nanog
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Homeobox protein NANOG
|