|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Homeobox_protein_NANOG
gptkb:hNanog
FLJ12581
|
|
gptkbp:associatedWith
|
stem cell biology
|
|
gptkbp:biologicalProcess
|
cell fate determination
stem cell maintenance
transcription regulation
DNA binding
|
|
gptkbp:discoveredBy
|
gptkb:Austin_Smith
|
|
gptkbp:downregulatedDuring
|
differentiation
|
|
gptkbp:encodes
|
gptkb:NANOG_protein
|
|
gptkbp:Entrez_Gene_ID
|
79923
ENSG00000111704
|
|
gptkbp:expressedIn
|
gptkb:testicular_germ_cell_tumors
embryonic stem cells
early embryogenesis
|
|
gptkbp:firstDescribed
|
2003
|
|
gptkbp:function
|
maintenance of pluripotency
self-renewal of embryonic stem cells
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
20857
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NANOG gene
|
|
gptkbp:length
|
305 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13.31
gptkb:chromosome_12
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
germ cell tumors
|
|
gptkbp:OMIM
|
607937
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Nanog (mouse gene)
|
|
gptkbp:pathway
|
Transcriptional regulation of pluripotent stem cells
Pluripotency of stem cells pathway
|
|
gptkbp:proteinFamily
|
homeobox proteins
|
|
gptkbp:regulates
|
gptkb:OCT4
gptkb:SOX2
gptkb:Wnt_signaling
gptkb:NANOG_protein
TGF-beta signaling
pluripotency network
LIF signaling
|
|
gptkbp:relatedTo
|
cellular reprogramming
cancer stem cells
|
|
gptkbp:sequence
|
915 base pairs
|
|
gptkbp:structure
|
contains homeodomain
|
|
gptkbp:symbol
|
gptkb:NANOG
|
|
gptkbp:UniProtID
|
Q9H9S0
|
|
gptkbp:upregulatedBy
|
pluripotent stem cells
|
|
gptkbp:bfsParent
|
gptkb:Nanog
gptkb:POU5F1_gene
gptkb:SOX2_gene
|
|
gptkbp:bfsLayer
|
7
|