|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:GON-10
gptkb:HD1
gptkb:RPD3
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
DNA repair
cell cycle regulation
gene silencing
NAD-independent histone deacetylase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
Taunton et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:encodes
|
gptkb:Histone_deacetylase_1
|
|
gptkbp:Entrez_Gene_ID
|
3065
ENSG00000116478
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
histone deacetylation
transcriptional regulation
chromatin remodeling
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
4852
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HDAC1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:trichostatin_A
gptkb:vorinostat
|
|
gptkbp:interactsWith
|
gptkb:HDAC2
gptkb:RB1
gptkb:SIN3A
gptkb:YY1
MTA2
|
|
gptkbp:length
|
482 amino acids
~25 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p35.2
|
|
gptkbp:mutationAssociatedWith
|
developmental defects
altered cell proliferation
|
|
gptkbp:OMIM
|
601241
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hdac1
|
|
gptkbp:pathway
|
gptkb:Notch_signaling_pathway
gptkb:Wnt_signaling_pathway
p53 signaling pathway
|
|
gptkbp:protein_mass
|
55 kDa
|
|
gptkbp:proteinFamily
|
gptkb:enzyme
histone deacetylase family
|
|
gptkbp:RefSeq
|
gptkb:NM_004964
|
|
gptkbp:UniProtID
|
Q13547
|
|
gptkbp:bfsParent
|
gptkb:HDAC1
|
|
gptkbp:bfsLayer
|
7
|