|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:Histone_deacetylase_A
gptkb:RPD3
gptkb:HDAC1
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:EC_number
|
3.5.1.98
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000116478
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1996
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:function
|
regulates gene expression
removes acetyl groups from lysine residues on histone proteins
regulates chromatin structure
|
|
gptkbp:gene
|
gptkb:HDAC1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Histone deacetylase 1
|
|
gptkbp:inhibitedBy
|
gptkb:valproic_acid
gptkb:sodium_butyrate
gptkb:trichostatin_A
|
|
gptkbp:interactsWith
|
gptkb:RbAp48
gptkb:CoREST
gptkb:NuRD_complex
gptkb:Sin3A
|
|
gptkbp:involves
|
cell cycle regulation
epigenetic regulation
transcriptional repression
|
|
gptkbp:locatedIn
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:1p35.2
|
|
gptkbp:member
|
gptkb:class_I_HDACs
histone deacetylase family
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:OMIM
|
601241
|
|
gptkbp:orthologInMouse
|
gptkb:Hdac1
|
|
gptkbp:orthologInYeast
|
gptkb:RPD3
|
|
gptkbp:PDB
|
4BKX
|
|
gptkbp:product
|
gptkb:HDAC1_gene
|
|
gptkbp:RefSeq
|
gptkb:NP_004955.2
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
|
|
gptkbp:structure
|
contains deacetylase domain
|
|
gptkbp:target
|
HDAC inhibitors
|
|
gptkbp:UniProtID
|
Q13547
|
|
gptkbp:bfsParent
|
gptkb:HDAC1
|
|
gptkbp:bfsLayer
|
7
|