|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:Heparin-binding_EGF-like_growth_factor
DTR
Hbegf precursor
|
|
gptkbp:discoveredBy
|
gptkb:Higashiyama_et_al.
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:HBEGF_gene
|
|
gptkbp:Entrez_Gene_ID
|
1839
ENSG00000142959
|
|
gptkbp:expressedIn
|
upregulated in inflammation
widely expressed in human tissues
upregulated in injury
|
|
gptkbp:fullName
|
gptkb:Heparin-binding_EGF-like_growth_factor
|
|
gptkbp:function
|
growth factor
binds heparin
binds EGF receptor
|
|
gptkbp:gene
|
gptkb:HBEGF
|
|
gptkbp:GO
|
GO:0008083 (growth factor activity)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0005102 (signaling receptor binding)
|
|
gptkbp:HGNC_ID
|
4838
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HBEGF
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q31-q32
|
|
gptkbp:location
|
gptkb:cell_membrane
extracellular space
|
|
gptkbp:molecularWeight
|
22 kDa (precursor)
9 kDa (mature form)
|
|
gptkbp:OMIM
|
126150
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Hbegf
rat Hbegf
zebrafish hbegfa
|
|
gptkbp:PDB
|
1X0E
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:proteinFamily
|
gptkb:EGF_family
|
|
gptkbp:recipient
|
gptkb:EGFR
gptkb:ERBB4
|
|
gptkbp:relatedTo
|
gptkb:EGFR_signaling_pathway
cell proliferation
wound healing
angiogenesis
|
|
gptkbp:significance
|
implicated in cancer
implicated in atherosclerosis
implicated in cardiac hypertrophy
|
|
gptkbp:structure
|
contains EGF-like domain
contains heparin-binding domain
|
|
gptkbp:UniProtID
|
Q99075
|
|
gptkbp:bfsParent
|
gptkb:HB-EGF
|
|
gptkbp:bfsLayer
|
7
|