Heparin-binding EGF-like growth factor
GPTKB entity
Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:HB-EGF
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:discoveredBy |
gptkb:Higashiyama_et_al.
|
| gptkbp:discoveredIn |
1991
|
| gptkbp:encodedBy |
gptkb:HBEGF_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
growth factor activity
stimulates cell proliferation binds heparin induces mitogenesis |
| https://www.w3.org/2000/01/rdf-schema#label |
Heparin-binding EGF-like growth factor
|
| gptkbp:locatedOnChromosome |
5q31-q32
|
| gptkbp:location |
gptkb:cell_membrane
extracellular space |
| gptkbp:memberOf |
gptkb:EGF_family
|
| gptkbp:molecularWeight |
~22 kDa
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:postTranslationalModification |
proteolytic cleavage
|
| gptkbp:recipient |
gptkb:EGFR
gptkb:ERBB4 |
| gptkbp:role |
wound healing
cardiac development tumor progression |
| gptkbp:UniProtID |
Q99075
|
| gptkbp:bfsParent |
gptkb:HB-EGF
gptkb:P21802 |
| gptkbp:bfsLayer |
7
|