Glycogen synthase kinase-3 alpha

URI: https://gptkb.org/entity/Glycogen_synthase_kinase-3_alpha
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName GSK-3A
GSK3 alpha
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:diabetes_mellitus
bipolar disorder
gptkbp:enzymeCommissionNumber EC 2.7.11.26
gptkbp:expressedIn gptkb:skeletal_muscle
brain
liver
gptkbp:function serine/threonine protein kinase
regulation of glycogen metabolism
phosphorylation of glycogen synthase
gptkbp:gene gptkb:GSK3A
https://www.w3.org/2000/01/rdf-schema#label Glycogen synthase kinase-3 alpha
gptkbp:inhibitedBy gptkb:SB-216763
gptkb:Tideglusib
gptkb:CHIR99021
lithium
AR-A014418
gptkbp:involvedIn apoptosis
cell differentiation
cell proliferation
neurogenesis
glucose homeostasis
gptkbp:locatedOnChromosome 19q13.2
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 51 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Gsk3a
gptkbp:PDB gptkb:1Q4L
gptkbp:phosphorylates gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:proteinFamily gptkb:GSK3_family
gptkbp:regulates gptkb:Wnt_signaling_pathway
cell cycle
insulin signaling pathway
gptkbp:substrate gptkb:cyclin_D1
gptkb:CREB
gptkb:c-Myc
gptkbp:UniProtID gptkb:P49840
gptkbp:bfsParent gptkb:GSK-3α
gptkb:GSK3A
gptkbp:bfsLayer 7