|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:encodedBy
|
Gsk3a gene
|
|
gptkbp:Entrez_Gene_ID
|
5660 (human ortholog)
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.26
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
pancreas
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase-3_alpha
|
|
gptkbp:function
|
serine/threonine protein kinase
|
|
gptkbp:gene
|
gptkb:Gsk3a
|
|
gptkbp:hasIsoform
|
gptkb:GSK3A
|
|
gptkbp:hasParalog
|
gptkb:Gsk3b
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Gsk3a
|
|
gptkbp:inhibitedBy
|
gptkb:CHIR99021
gptkb:SB216763
lithium
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
glycogen metabolism
insulin signaling pathway
|
|
gptkbp:locatedOnChromosome
|
7
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:mouseGeneID
|
56637
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
GSK3A (human)
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:Wnt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:PDB
|
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
GSK-3 family
|
|
gptkbp:regulates
|
activated by phosphorylation
inhibited by insulin
|
|
gptkbp:structure
|
contains serine/threonine kinase domain
|
|
gptkbp:UniProtID
|
P18265
|
|
gptkbp:bfsParent
|
gptkb:GSK-3α
gptkb:GSK3A
|
|
gptkbp:bfsLayer
|
7
|