|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:G_proteins
|
|
gptkbp:alternativeName
|
gptkb:7TM_receptors
seven-transmembrane receptors
heptahelical receptors
|
|
gptkbp:binds
|
ligands
|
|
gptkbp:database
|
gptkb:GPCRdb
gptkb:IUPHAR/BPS_Guide_to_Pharmacology
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:encodedBy
|
GPCR genes
|
|
gptkbp:example
|
gptkb:receptor_tyrosine_kinase
gptkb:beta-adrenergic_receptor
gptkb:muscarinic_acetylcholine_receptor
gptkb:olfactory_receptor
gptkb:rhodopsin
dopamine receptor
|
|
gptkbp:foundIn
|
animals
fungi
plants
|
|
gptkbp:fullName
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:function
|
signal transduction
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GPCRs
|
|
gptkbp:involvedIn
|
sensory perception
immune response
neurotransmission
hormone response
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:modulatedBy
|
antagonists
allosteric modulators
agonists
inverse agonists
|
|
gptkbp:NobelPrizeYear
|
gptkb:1994_Nobel_Prize_in_Physiology_or_Medicine
|
|
gptkbp:numberOfGenes
|
over 800
|
|
gptkbp:pathway
|
gptkb:cAMP_pathway
ion channel regulation
phospholipase C pathway
|
|
gptkbp:significance
|
gptkb:cancer
cardiovascular diseases
neurological disorders
metabolic diseases
psychiatric disorders
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:subspecies
|
gptkb:Adhesion_GPCRs
gptkb:Class_A_(Rhodopsin-like)
gptkb:Class_B_(Secretin_receptor_family)
gptkb:Class_C_(Metabotropic_glutamate/pheromone)
Frizzled/Taste2
Other GPCRs
|
|
gptkbp:target
|
pharmaceutical drugs
|
|
gptkbp:bfsParent
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:bfsLayer
|
5
|