G protein-coupled receptor superfamily

URI: https://gptkb.org/entity/G_protein-coupled_receptor_superfamily

GPTKB entity

Statements (84)

Predicate	Object
gptkbp:instanceOf	superfamily
gptkbp:alsoKnownAs	gptkb:GPCR_superfamily
gptkbp:composedOf	gptkb:G_protein-coupled_receptors
gptkbp:contains	gptkb:cannabinoid_receptors gptkb:opioid_receptors gptkb:GPR_receptors gptkb:adhesion_GPCRs gptkb:angiotensin_receptors gptkb:biogenic_amine_receptors gptkb:chemokine_receptors gptkb:free_fatty_acid_receptors gptkb:glycoprotein_hormone_receptors gptkb:hydroxycarboxylic_acid_receptors gptkb:melatonin_receptors gptkb:muscarinic_acetylcholine_receptors gptkb:peptide_receptors gptkb:purinergic_receptors gptkb:secretin-like_receptors gptkb:succinate_receptors gptkb:trace_amine-associated_receptors gptkb:vasopressin_receptors adrenergic receptors dopamine receptors histamine receptors serotonin receptors olfactory receptors metabotropic glutamate receptors rhodopsin-like receptors melanocortin receptors bombesin receptors bradykinin receptors calcitonin receptors cholecystokinin receptors endothelin receptors follicle-stimulating hormone receptors frizzled/taste2 receptors galanin receptors glucagon receptors gonadotropin-releasing hormone receptors kisspeptin receptors luteinizing hormone receptors neuropeptide Y receptors neurotensin receptors orexin receptors parathyroid hormone receptors prostaglandin receptors somatostatin receptors tachykinin receptors thyrotropin receptors thyrotropin-releasing hormone receptors
gptkbp:database	Gene Ontology: GO:0004930 InterPro: IPR000276 PROSITE: PS50262 Pfam: PF00001
gptkbp:discoveredBy	gptkb:Martin_Rodbell gptkb:Alfred_G._Gilman
gptkbp:evolvesFrom	ancient eukaryotic ancestor
gptkbp:foundIn	eukaryotes
gptkbp:function	signal transduction cell communication
https://www.w3.org/2000/01/rdf-schema#label	G protein-coupled receptor superfamily
gptkbp:ligand	ions light lipids nucleotides hormones neurotransmitters peptides odorants
gptkbp:membraneLocation	gptkb:plasma_membrane
gptkbp:NobelPrizeYear	gptkb:1994_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:numberOfGenes	over 800
gptkbp:percentageOfDrugsTargeting	about 34% of all approved drugs
gptkbp:signalTransductionMechanism	G protein activation
gptkbp:significance	drug targets
gptkbp:structure	seven transmembrane alpha helices
gptkbp:subfamily	gptkb:Adhesion_GPCRs gptkb:Class_A_(Rhodopsin-like) gptkb:Class_C_(Metabotropic_glutamate/pheromone) gptkb:Class_B_(Secretin-like) gptkb:Class_F_(Frizzled/Smoothened) gptkb:Taste2_GPCRs
gptkbp:bfsParent	gptkb:Class_C_(Metabotropic_glutamate/pheromone)
gptkbp:bfsLayer	6