Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:encodedBy |
various genes
|
| gptkbp:example |
gptkb:CCR3
gptkb:CCR4 gptkb:CCR5 gptkb:CXCR2 gptkb:CXCR4 gptkb:CXCR1 CCR6 CX3CR1 CCR1 CCR2 CCR7 |
| gptkbp:expressedIn |
gptkb:leukocytes
neurons endothelial cells epithelial cells |
| gptkbp:function |
bind chemokines
mediate cell signaling regulate leukocyte migration |
| gptkbp:GO_term |
GO:0004950
|
| https://www.w3.org/2000/01/rdf-schema#label |
chemokine receptors
|
| gptkbp:involvedIn |
B cell migration
allergic reactions inflammatory response neutrophil migration tumor progression lymphocyte homing monocyte migration HIV entry into cells T cell migration |
| gptkbp:ligand |
chemokines
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:relatedTo |
signal transduction
immune cell trafficking chemotaxis chemokines |
| gptkbp:role |
HIV infection
autoimmune diseases inflammation immune response cancer metastasis |
| gptkbp:structure |
gptkb:G_protein-coupled_receptor
|
| gptkbp:subclassOf |
gptkb:G_protein-coupled_receptors
|
| gptkbp:target |
monoclonal antibodies
antagonists therapeutic drugs |
| gptkbp:bfsParent |
gptkb:Class_A_(Rhodopsin-like)
gptkb:GPCR_family |
| gptkbp:bfsLayer |
6
|