|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
ligand binding
|
|
gptkbp:alternativeName
|
seven-transmembrane receptors
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
neurological disorders
metabolic disorders
|
|
gptkbp:contains
|
gptkb:adhesion_GPCRs
gptkb:secretin-like_receptors
olfactory receptors
metabotropic glutamate receptors
rhodopsin-like receptors
frizzled/taste2 receptors
|
|
gptkbp:database
|
InterPro: IPR000276
PROSITE: PS50262
Pfam: PF00001
|
|
gptkbp:discoveredBy
|
gptkb:Martin_Rodbell
gptkb:Alfred_G._Gilman
|
|
gptkbp:downstreamOf
|
ion channel regulation
gene expression modulation
second messenger production
|
|
gptkbp:evolvesFrom
|
ancient eukaryotes
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:fullName
|
gptkb:G_protein-coupled_receptor_superfamily
|
|
gptkbp:function
|
signal transduction
|
|
gptkbp:geneCountInHuman
|
over 800
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GPCR superfamily
|
|
gptkbp:importantFor
|
drug targets
|
|
gptkbp:ligand
|
ions
light
hormones
neurotransmitters
odorants
|
|
gptkbp:locale
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
membrane proteins
|
|
gptkbp:NobelPrizeYear
|
gptkb:Robert_Lefkowitz
gptkb:Brian_Kobilka
Nobel Prize in Chemistry 2012
|
|
gptkbp:pharmacologicalImportance
|
target of ~30% of all drugs
|
|
gptkbp:signalMechanism
|
G protein activation
|
|
gptkbp:structure
|
extracellular N-terminus
intracellular C-terminus
seven transmembrane alpha helices
|
|
gptkbp:subfamily
|
gptkb:Adhesion_GPCRs
gptkb:Class_A_(Rhodopsin-like)
gptkb:Class_C_(Metabotropic_glutamate/pheromone)
gptkb:Class_B_(Secretin-like)
gptkb:Class_F_(Frizzled/Smoothened)
Taste2 receptors
|
|
gptkbp:bfsParent
|
gptkb:Class_F_(Frizzled/Taste2)
|
|
gptkbp:bfsLayer
|
6
|