muscarinic acetylcholine receptors
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:G_protein-coupled_receptor |
| gptkbp:binds |
gptkb:acetylcholine
|
| gptkbp:discoveredBy |
gptkb:Henry_Hallett_Dale
|
| gptkbp:drugClass |
cholinergic receptor
|
| gptkbp:effect |
smooth muscle contraction
decrease heart rate increase glandular secretion |
| gptkbp:encodedBy |
gptkb:CHRM1
gptkb:CHRM2 gptkb:CHRM3 gptkb:CHRM4 gptkb:CHRM5 |
| gptkbp:enemyOf |
gptkb:muscarine
gptkb:pilocarpine scopolamine atropine tiotropium ipratropium |
| gptkbp:expressedIn |
brain
heart exocrine glands smooth muscle |
| gptkbp:foundIn |
central nervous system
peripheral nervous system |
| gptkbp:function |
modulate heart rate
mediate glandular secretion regulate smooth muscle contraction |
| https://www.w3.org/2000/01/rdf-schema#label |
muscarinic acetylcholine receptors
|
| gptkbp:involvedIn |
parasympathetic nervous system
|
| gptkbp:medicalUse |
treatment of asthma
treatment of bradycardia treatment of overactive bladder treatment of COPD |
| gptkbp:modulatedBy |
acetylcholinesterase inhibitors
anticholinergic drugs |
| gptkbp:namedAfter |
gptkb:muscarine
|
| gptkbp:relatedTo |
nicotinic acetylcholine receptors
|
| gptkbp:structure |
seven transmembrane domains
|
| gptkbp:subspecies |
M1 receptor
M2 receptor M3 receptor M4 receptor M5 receptor |
| gptkbp:type |
gptkb:Gi_protein
gptkb:Gq_protein Go protein |
| gptkbp:bfsParent |
gptkb:rhodopsin-like_receptor
gptkb:Class_A_(Rhodopsin-like) |
| gptkbp:bfsLayer |
6
|