muscarinic acetylcholine receptors

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:binds	gptkb:acetylcholine
gptkbp:discoveredBy	gptkb:Henry_Hallett_Dale
gptkbp:drugClass	cholinergic receptor
gptkbp:effect	smooth muscle contraction decrease heart rate increase glandular secretion
gptkbp:encodedBy	gptkb:CHRM1 gptkb:CHRM2 gptkb:CHRM3 gptkb:CHRM4 gptkb:CHRM5
gptkbp:enemyOf	gptkb:muscarine gptkb:pilocarpine scopolamine atropine tiotropium ipratropium
gptkbp:expressedIn	brain heart exocrine glands smooth muscle
gptkbp:foundIn	central nervous system peripheral nervous system
gptkbp:function	modulate heart rate mediate glandular secretion regulate smooth muscle contraction
gptkbp:involvedIn	parasympathetic nervous system
gptkbp:medicalUse	treatment of asthma treatment of bradycardia treatment of overactive bladder treatment of COPD
gptkbp:modulatedBy	acetylcholinesterase inhibitors anticholinergic drugs
gptkbp:namedAfter	gptkb:muscarine
gptkbp:relatedTo	nicotinic acetylcholine receptors
gptkbp:structure	seven transmembrane domains
gptkbp:subspecies	M1 receptor M2 receptor M3 receptor M4 receptor M5 receptor
gptkbp:type	gptkb:Gi_protein gptkb:Gq_protein Go protein
gptkbp:bfsParent	gptkb:G_protein-coupled_receptor_superfamily gptkb:Class_A_(Rhodopsin-like) gptkb:Gi/o_protein_pathway gptkb:rhodopsin-like_GPCRs gptkb:rhodopsin-like_GPCR_family gptkb:Class_A_GPCRs
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	muscarinic acetylcholine receptors