|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:enkephalins
opioids
dynorphins
endorphins
|
|
gptkbp:discoveredBy
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:OPRD1_gene
gptkb:OPRK1_gene
gptkb:OPRL1_gene
gptkb:OPRM1_gene
|
|
gptkbp:enemyOf
|
gptkb:methadone
gptkb:oxycodone
gptkb:morphine
gptkb:naloxone
gptkb:naltrexone
amphetamine
fentanyl
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
gptkb:award
addiction
constipation
pain modulation
respiratory depression
sedation
euphoria
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
opioid receptors
|
|
gptkbp:location
|
gptkb:spinal_cord
brain
gastrointestinal tract
|
|
gptkbp:medicalUse
|
pain management
anesthesia
cough suppression
diarrhea treatment
|
|
gptkbp:overactivationEffect
|
addiction
nausea
tolerance
vomiting
constipation
respiratory depression
sedation
euphoria
physical dependence
|
|
gptkbp:subspecies
|
gptkb:nociceptin_receptor
gptkb:delta-opioid_receptor
gptkb:kappa-opioid_receptor
gptkb:mu-opioid_receptor
|
|
gptkbp:type
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:bfsParent
|
gptkb:Class_A_(Rhodopsin-like)
|
|
gptkbp:bfsLayer
|
6
|