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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
|
seven-transmembrane receptors
heptahelical receptors
7-transmembrane domain receptors
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gptkbp:C-terminusLocation
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intracellular
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gptkbp:component
|
gptkb:cell_membrane
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gptkbp:database
|
InterPro: IPR000276
PROSITE: PS50262
Pfam: PF00001
UniProtKB family: 7tm_1
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gptkbp:discoveredBy
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gptkb:Robert_J._Lefkowitz
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gptkbp:evolvesFrom
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ancient protein family
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gptkbp:example
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gptkb:receptor_tyrosine_kinase
gptkb:angiotensin_receptor
gptkb:beta-adrenergic_receptor
gptkb:muscarinic_acetylcholine_receptor
gptkb:rhodopsin
dopamine receptor
opioid
antihistamine
chemokine receptor
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gptkbp:foundIn
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eukaryotes
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gptkbp:function
|
signal transduction
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gptkbp:GO_term
|
GO:0004930
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|
https://www.w3.org/2000/01/rdf-schema#label
|
7TM receptors
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gptkbp:ligand
|
ions
light
hormones
neurotransmitters
peptides
odorants
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gptkbp:mechanismOfAction
|
activate G proteins
initiate intracellular signaling cascades
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gptkbp:mutationAssociatedWith
|
can cause disease
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gptkbp:N-terminusLocation
|
extracellular
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gptkbp:numberOfGenes
|
over 800
|
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gptkbp:pharmacologicalImportance
|
target of ~30% of marketed drugs
|
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gptkbp:researchArea
|
gptkb:pharmacy
biochemistry
molecular biology
|
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gptkbp:signalTransductionPathway
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gptkb:MAPK_pathway
gptkb:cAMP_pathway
phospholipase C pathway
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gptkbp:significance
|
drug targets
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gptkbp:structure
|
seven transmembrane alpha helices
|
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gptkbp:subclassOf
|
gptkb:G_protein-coupled_receptors
cell surface receptor
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gptkbp:bfsParent
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gptkb:GPCRs
gptkb:GPCR_family
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gptkbp:bfsLayer
|
6
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