Guanine nucleotide releasing factors
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:GEFs
|
| gptkbp:alsoKnownAs |
Guanine nucleotide exchange factors
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:example |
gptkb:Dbl_family_proteins
gptkb:RasGRF gptkb:eIF2B gptkb:Vav gptkb:SOS1 |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
activate GTPases
|
| https://www.w3.org/2000/01/rdf-schema#label |
Guanine nucleotide releasing factors
|
| gptkbp:involvedIn |
cell differentiation
vesicle trafficking cell growth cell signaling cytoskeletal organization oncogenesis |
| gptkbp:mechanismOfAction |
promote exchange of GDP for GTP
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
developmental disorders |
| gptkbp:regulates |
heterotrimeric G proteins
small G proteins |
| gptkbp:target |
post-translational modifications
regulatory proteins |
| gptkbp:bfsParent |
gptkb:GEFs
|
| gptkbp:bfsLayer |
7
|