Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
schizophrenia intellectual disability |
| gptkbp:discoveredIn |
1997
|
| gptkbp:domain |
gptkb:PH_domain
gptkb:RhoGEF_domain SH3 domain Ig-like domain spectrin repeat |
| gptkbp:encodedBy |
KALRN gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
guanine nucleotide exchange factor
neuronal development regulation of cytoskeleton |
| https://www.w3.org/2000/01/rdf-schema#label |
Kalirin
|
| gptkbp:interactsWith |
gptkb:PAK1
gptkb:DISC1 gptkb:Rac1 |
| gptkbp:locatedOnChromosome |
3q21
|
| gptkbp:location |
gptkb:cytoplasm
neurons |
| gptkbp:molecularWeight |
~370 kDa (largest isoform)
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:role |
gptkb:synaptic_plasticity
learning and memory axon guidance dendritic spine morphogenesis |
| gptkbp:UniProtID |
O60229
|
| gptkbp:bfsParent |
gptkb:GEFs
|
| gptkbp:bfsLayer |
7
|