|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:RAPGEF1
gptkb:Crk_SH3-binding_guanine_nucleotide-releasing_factor
gptkb:GRF2
|
|
gptkbp:associatedWith
|
leukemia
neuronal differentiation
cell adhesion
hematopoiesis
|
|
gptkbp:discoveredBy
|
gptkb:Hideo_Miyazaki
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:Entrez_Gene_ID
|
10451
ENSG00000127920
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Rap_guanine_nucleotide_exchange_factor_1
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:gene
|
gptkb:RAPGEF1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
C3G
|
|
gptkbp:interactsWith
|
gptkb:Crk
gptkb:Rap1
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:locatedIn
|
gptkb:Homo_sapiens
|
|
gptkbp:locatedOnChromosome
|
9q34.3
|
|
gptkbp:molecularWeight
|
~140 kDa
|
|
gptkbp:OMIM
|
600046
|
|
gptkbp:phosphorylates
|
Serine 233
Tyrosine 504
|
|
gptkbp:regulates
|
cell proliferation
cell migration
Rap1 activation
|
|
gptkbp:UniProtID
|
Q13905
|
|
gptkbp:bfsParent
|
gptkb:RAPGEF1
gptkb:GEFs_(guanine_nucleotide_exchange_factors)
|
|
gptkbp:bfsLayer
|
6
|