Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:abbreviation |
gptkb:GEF
|
| gptkbp:activatedBy |
gptkb:Ras_proteins
Arf proteins Rab proteins Ran proteins Rho proteins |
| gptkbp:discoveredBy |
1980s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurological disorders immune diseases |
| gptkbp:example |
gptkb:Dbl_family
gptkb:RasGRF gptkb:eIF2B gptkb:Vav gptkb:SOS1 ArfGEF RabGEF RanGEF RhoGEF |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
activate GTPases
catalyze exchange of GDP for GTP |
| https://www.w3.org/2000/01/rdf-schema#label |
Guanine exchange factors
|
| gptkbp:involves |
signal transduction
cell cycle regulation immune response neurotransmission oncogenesis |
| gptkbp:opposedBy |
GTPase-activating proteins
|
| gptkbp:regulates |
cell differentiation
gene expression vesicle trafficking cell growth cell migration cell polarity cell adhesion cell signaling pathways cytoskeletal organization membrane trafficking GDP/GTP cycle |
| gptkbp:requires |
GTPase activation
|
| gptkbp:structure |
contain CDC25 domain
contain DH domain contain PH domain contain Sec7 domain |
| gptkbp:target |
small GTPases
|
| gptkbp:bfsParent |
gptkb:GEFs
|
| gptkbp:bfsLayer |
7
|