|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:GADD45A
Growth arrest and DNA-damage-inducible protein alpha
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
inflammatory response
|
|
gptkbp:downregulatedIn
|
some cancers
|
|
gptkbp:encodedBy
|
GADD45A gene
|
|
gptkbp:Entrez_Gene_ID
|
1647
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GADD45 alpha
|
|
gptkbp:interactsWith
|
gptkb:MAPK_pathway
gptkb:p21
gptkb:PCNA
gptkb:CDK1
|
|
gptkbp:involvedIn
|
apoptosis
DNA repair
DNA damage response
cell cycle arrest
|
|
gptkbp:length
|
165 amino acids
|
|
gptkbp:locatedOnChromosome
|
1p31.2
|
|
gptkbp:molecularWeight
|
18 kDa
|
|
gptkbp:OMIM
|
126335
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
GADD45 beta
GADD45 gamma
|
|
gptkbp:participatedIn
|
cellular senescence
G2/M checkpoint
|
|
gptkbp:phosphorylates
|
Serine 89
Threonine 82
|
|
gptkbp:regulates
|
gptkb:NF-kB
gptkb:JNK_pathway
gptkb:p38_MAPK_pathway
gptkb:BRCA1
gptkb:p53
cell growth
cellular stress response
cellular differentiation
DNA demethylation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:P24522
|
|
gptkbp:upregulatedBy
|
UV radiation
oxidative stress
genotoxic stress
|
|
gptkbp:bfsParent
|
gptkb:GADD45A
|
|
gptkbp:bfsLayer
|
7
|