autoimmune lymphoproliferative syndrome (ALPS)

GPTKB entity

Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:disease
autoimmune disease
lymphoproliferative disorder
gptkbp:abbreviation gptkb:ALPS
gptkbp:affects immune system
lymphatic system
gptkbp:causedBy mutation in CASP10 gene
mutation in FAS gene
mutation in FASLG gene
gptkbp:complication increased risk of lymphoma
gptkbp:describedBy OMIM:601859
Orphanet:ORPHA:326
gptkbp:firstDescribed 1990s
gptkbp:hasBiomarker elevated IL-10
elevated double-negative T cells
elevated soluble FAS ligand
elevated vitamin B12
https://www.w3.org/2000/01/rdf-schema#label autoimmune lymphoproliferative syndrome (ALPS)
gptkbp:ICD-10_code D47.Z2
gptkbp:inheritance autosomal dominant
autosomal recessive
gptkbp:onset childhood
gptkbp:symptom splenomegaly
lymphadenopathy
hepatomegaly
autoimmune cytopenias
gptkbp:treatment gptkb:sirolimus
gptkb:mycophenolate_mofetil
immunosuppressive therapy
corticosteroids
gptkbp:bfsParent gptkb:FAS_gene
gptkb:Fas_ligand_(FasL)
gptkbp:bfsLayer 7