|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:DRD2_gene
gptkb:DRD3_gene
gptkb:DRD5_gene
DRD1 gene
DRD4 gene
|
|
gptkbp:enemyOf
|
gptkb:chlorpromazine
gptkb:clozapine
gptkb:haloperidol
dopamine
apomorphine
bromocriptine
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
retina
blood vessels
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
binds dopamine
mediates neurotransmission
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dopamine Receptor
|
|
gptkbp:location
|
central nervous system
peripheral nervous system
|
|
gptkbp:MeSH_ID
|
D004298
|
|
gptkbp:OMIM
|
126450
|
|
gptkbp:relatedTo
|
gptkb:Parkinson's_disease
gptkb:depression
addiction
bipolar disorder
schizophrenia
|
|
gptkbp:role
|
cognition
motor control
endocrine regulation
reward pathway
|
|
gptkbp:structure
|
7 transmembrane domains
|
|
gptkbp:subclassOf
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:subspecies
|
gptkb:D1_receptor
gptkb:D2_receptor
gptkb:D3_receptor
gptkb:D4_receptor
gptkb:D5_receptor
|
|
gptkbp:target
|
antipsychotic drugs
dopaminergic drugs
|
|
gptkbp:type
|
gptkb:cAMP_pathway
phospholipase C pathway
|
|
gptkbp:UniProtID
|
gptkb:P21728
|
|
gptkbp:bfsParent
|
gptkb:DARS
|
|
gptkbp:bfsLayer
|
8
|