|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:dopamine_receptor_D3
gptkb:dopamine_D3_receptor
D3DR
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
bipolar disorder
schizophrenia
drug addiction
neuropsychiatric disorders
|
|
gptkbp:discoveredBy
|
1990
|
|
gptkbp:encodes
|
Dopamine receptor D3
|
|
gptkbp:Entrez_Gene_ID
|
1814
ENSG00000127831
|
|
gptkbp:expressedIn
|
brain
limbic system
|
|
gptkbp:firstDescribed
|
1990
Sokoloff et al.
|
|
gptkbp:function
|
G-protein coupled receptor activity
dopamine receptor activity
|
|
gptkbp:gene
|
gptkb:DRD3
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3025
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DRD3 gene
|
|
gptkbp:length
|
400 amino acids
~40 kb
|
|
gptkbp:locatedOnChromosome
|
3
3q13.31
|
|
gptkbp:mRNA_length
|
~2.5 kb
|
|
gptkbp:mutationAssociatedWith
|
gptkb:essential_tremor
gptkb:autism_spectrum_disorder
|
|
gptkbp:OMIM
|
126451
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Drd3
|
|
gptkbp:pathway
|
neuroactive ligand-receptor interaction
dopaminergic synapse
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
regulated by antipsychotic drugs
regulated by dopamine
|
|
gptkbp:structure
|
7 transmembrane helices
|
|
gptkbp:targetOfDrug
|
gptkb:cariprazine
antipsychotic drugs
pramipexole
ropinirole
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:type
|
inhibits adenylyl cyclase
|
|
gptkbp:UniProtID
|
gptkb:P35462
|
|
gptkbp:bfsParent
|
gptkb:dopamine_receptor_D3
gptkb:Dopamine_D3_Receptor
|
|
gptkbp:bfsLayer
|
7
|