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gptkbp:instanceOf
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gptkb:protein
dopamine receptor
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gptkbp:alternativeName
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dopamine D2 receptor
D2R
DRD2
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gptkbp:associatedWith
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gptkb:Parkinson's_disease
addiction
bipolar disorder
schizophrenia
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gptkbp:binds
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antipsychotic drugs
antagonists
dopamine
agonists
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gptkbp:encodedBy
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gptkb:DRD2_gene
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gptkbp:expressedIn
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gptkb:cancer
gptkb:striatum
gptkb:pituitary_gland
gptkb:ventral_tegmental_area
gptkb:adrenal_gland
gptkb:kidney
gptkb:spinal_cord
gptkb:cortex
gptkb:nucleus_accumbens
gptkb:olfactory_tubercle
heart
gastrointestinal tract
retina
substantia nigra
hippocampus
amygdala
hypothalamus
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gptkbp:foundIn
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central nervous system
peripheral nervous system
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gptkbp:function
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gptkb:G_protein-coupled_receptor
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gptkbp:hasIsoform
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D2L (long) isoform
D2S (short) isoform
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gptkbp:HGNC_ID
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3024
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https://www.w3.org/2000/01/rdf-schema#label
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D2 receptor
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gptkbp:involvedIn
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motor control
modulation of neurotransmission
reward pathway
prolactin inhibition
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gptkbp:locatedIn
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gptkb:cell_membrane
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gptkbp:locatedOnChromosome
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gptkb:chromosome_11q23.2
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gptkbp:molecularWeight
|
~51 kDa
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gptkbp:OMIM
|
126450
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gptkbp:orthologIn
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gptkb:mouse_Drd2
gptkb:rat_Drd2
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gptkbp:structure
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seven transmembrane domains
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gptkbp:subspecies
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gptkb:dopamine_receptor_family
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gptkbp:target
|
antipsychotic medications
Parkinson's disease drugs
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gptkbp:type
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inhibits adenylyl cyclase
activates potassium channels
inhibits calcium channels
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gptkbp:UniProtID
|
P14416
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gptkbp:bfsParent
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gptkb:Dopamine_(in_brain)
gptkb:D2-like_receptor_family
gptkb:D2-like_receptors
gptkb:dopamine_receptor_family
gptkb:Dopamine_Receptor_D
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gptkbp:bfsLayer
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8
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